{"id":198,"date":"2026-07-27T19:18:50","date_gmt":"2026-07-27T19:18:50","guid":{"rendered":"https:\/\/epinutrition.org\/?page_id=198"},"modified":"2026-08-20T15:43:55","modified_gmt":"2026-08-20T15:43:55","slug":"abnormal-cell-behavior","status":"publish","type":"page","link":"https:\/\/epinutrition.org\/?page_id=198","title":{"rendered":"Colon Cell Life Cycle"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">When the Balance Between Cell Renewal and Cell Removal Begins to Change<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\">The colon lining is one of the body\u2019s most actively renewed tissues. New epithelial cells arise near the base of the colonic crypt, mature as they move toward the intestinal surface, perform specialized functions, and are eventually removed and replaced.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6acc31ba30fa8&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"6acc31ba30fa8\" class=\"aligncenter size-large wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"683\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on--pointerdown=\"actions.preloadImage\" data-wp-on--pointerenter=\"actions.preloadImageWithDelay\" data-wp-on--pointerleave=\"actions.cancelPreload\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/epinutrition.org\/wp-content\/uploads\/2026\/08\/cell-life-cycle-1024x683.png\" alt=\"This continual renewal depends on a carefully regulated balance among:\n\nCell proliferation\n\nMaturation and differentiation\n\nDNA repair and stress responses\n\nProgrammed cell death, or apoptosis\n\nRemoval of aging or damaged cells\n\nMaintenance of the intestinal barrier\" class=\"wp-image-911\" srcset=\"https:\/\/epinutrition.org\/wp-content\/uploads\/2026\/08\/cell-life-cycle-1024x683.png 1024w, https:\/\/epinutrition.org\/wp-content\/uploads\/2026\/08\/cell-life-cycle-300x200.png 300w, https:\/\/epinutrition.org\/wp-content\/uploads\/2026\/08\/cell-life-cycle-768x512.png 768w, https:\/\/epinutrition.org\/wp-content\/uploads\/2026\/08\/cell-life-cycle.png 1536w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\tdata-wp-bind--aria-label=\"state.thisImage.triggerButtonAriaLabel\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.thisImage.buttonRight\"\n\t\t\tdata-wp-style--top=\"state.thisImage.buttonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">When Abnormal Cell Behavior Begins<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Abnormal cell behavior begins when parts of this coordinated system become persistently altered. Cells may divide when they should remain quiet, fail to mature normally, respond differently to stress, or remain alive when they would ordinarily be removed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">These changes do not necessarily mean that a cell is cancerous. Many molecular safeguards must be disrupted before a cell can form a persistent abnormal clone or visible lesion.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Metabolism Can Influence Cell Behavior<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Cellular metabolism does more than generate energy. It also determines the availability of molecules used in signaling, antioxidant defense, DNA synthesis, and the chemical modification of proteins and chromatin.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A Warburg-like metabolic pattern can therefore be associated with changes in:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Growth and survival signaling<\/li>\n\n\n\n<li>Cellular stress responses<\/li>\n\n\n\n<li>Redox balance<\/li>\n\n\n\n<li>Production of materials needed for cell division<\/li>\n\n\n\n<li>Regulation of gene activity<\/li>\n\n\n\n<li>Interactions with immune and inflammatory signals<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Metabolism and gene regulation influence one another. Genetic or epigenetic changes can alter metabolism, while metabolic changes can affect signaling and chromatin regulation.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The direction of cause and effect may differ among cells and stages of disease.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">From an Altered Cell to a Visible Lesion<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">A single abnormal cell does not inevitably become a polyp or cancer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For an altered cell population to persist, some cells must gain a selective advantage within the colonic crypt. Over time, additional genetic, epigenetic, metabolic, and environmental changes may allow an abnormal clone to expand.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Adenomas and serrated lesions are themselves biologically diverse. Studies of human precursor lesions show different patterns of proliferation, apoptosis, and regulatory proteins, reinforcing that colorectal carcinogenesis does not follow one identical pathway in every person.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Screening can identify and remove many of these visible precursor lesions before they progress further.<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;6acc31ba31805&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"6acc31ba31805\" class=\"wp-block-image size-full is-resized wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"1800\" height=\"1300\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on--pointerdown=\"actions.preloadImage\" data-wp-on--pointerenter=\"actions.preloadImageWithDelay\" data-wp-on--pointerleave=\"actions.cancelPreload\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/epinutrition.org\/wp-content\/uploads\/2026\/07\/abnormal-cell-behavior.png\" alt=\"Diagram comparing normal colon-lining renewal with a proposed path toward persistent abnormal cell behavior. Normal renewal balances controlled proliferation, differentiation, barrier function, and cell removal. A proposed divergence involves altered metabolism and signaling, changed gene regulation, growth\u2013removal imbalance, and expansion of a persistent abnormal clone. This transition is a hypothesis, not a cancer diagnosis or inevitable sequence.\" class=\"wp-image-199\" style=\"width:1178px;height:auto\" srcset=\"https:\/\/epinutrition.org\/wp-content\/uploads\/2026\/07\/abnormal-cell-behavior.png 1800w, https:\/\/epinutrition.org\/wp-content\/uploads\/2026\/07\/abnormal-cell-behavior-300x217.png 300w, https:\/\/epinutrition.org\/wp-content\/uploads\/2026\/07\/abnormal-cell-behavior-1024x740.png 1024w, https:\/\/epinutrition.org\/wp-content\/uploads\/2026\/07\/abnormal-cell-behavior-768x555.png 768w, https:\/\/epinutrition.org\/wp-content\/uploads\/2026\/07\/abnormal-cell-behavior-1536x1109.png 1536w\" sizes=\"auto, (max-width: 1800px) 100vw, 1800px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\tdata-wp-bind--aria-label=\"state.thisImage.triggerButtonAriaLabel\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.thisImage.buttonRight\"\n\t\t\tdata-wp-style--top=\"state.thisImage.buttonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">References<\/h2>\n\n\n\n<ol start=\"1\" class=\"wp-block-list\">\n<li>Figueiredo JC, Passarelli MN, Wei W, Ahnen DJ, Morris JS, Corley L, et al. Proliferation, apoptosis and their regulatory protein expression in colorectal adenomas and serrated lesions. <em>PLoS One.<\/em> 2021;16(11). doi: <a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0258878\">10.1371\/journal.pone.0258878<\/a>. PMID: 34762658; PMCID: PMC8580290.<\/li>\n\n\n\n<li>Donohoe DR, Collins LB, Wali A, Bigler R, Sun W, Bultman SJ. The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation. <em>Molecular Cell.<\/em> 2012;48(4):612\u2013626. doi: <a href=\"https:\/\/doi.org\/10.1016\/j.molcel.2012.08.033\">10.1016\/j.molcel.2012.08.033<\/a>. PMID: 23063526; PMCID: PMC3513569.<\/li>\n\n\n\n<li>Dela Cruz M, Ledbetter S, Chowdhury S, Tiwari AK, Momi N, Wali RK, et al. Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis. <em>Oncotarget.<\/em> 2017;8(13):20543\u201320557. doi: <a href=\"https:\/\/doi.org\/10.18632\/oncotarget.16129\">10.18632\/oncotarget.16129<\/a>. PMID: 28423551; PMCID: PMC5400525.<\/li>\n<\/ol>\n\n\n\n<div class=\"wp-block-buttons is-content-justification-right is-layout-flex wp-container-core-buttons-is-layout-89b4c9e9 wp-block-buttons-is-layout-flex\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link wp-element-button\" href=\"https:\/\/epinutrition.org\/?page_id=202\" style=\"border-top-left-radius:46px;border-top-right-radius:46px;border-bottom-left-radius:46px;border-bottom-right-radius:46px\">Next: Benign Adenoma\u2192<\/a><\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>When the Balance Between Cell Renewal and Cell Removal Begins to Change The colon lining is one of the body\u2019s most actively renewed tissues. New epithelial cells arise near the base of the colonic crypt, mature as they move toward the intestinal surface, perform specialized functions, and are eventually removed and replaced. When Abnormal Cell&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"pmpro_default_level":"","_kad_post_transparent":"","_kad_post_title":"hide","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"_kad_post_classname":"","footnotes":""},"class_list":["post-198","page","type-page","status-publish","hentry","pmpro-has-access"],"brizy_media":[],"_links":{"self":[{"href":"https:\/\/epinutrition.org\/index.php?rest_route=\/wp\/v2\/pages\/198","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/epinutrition.org\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/epinutrition.org\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/epinutrition.org\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/epinutrition.org\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=198"}],"version-history":[{"count":5,"href":"https:\/\/epinutrition.org\/index.php?rest_route=\/wp\/v2\/pages\/198\/revisions"}],"predecessor-version":[{"id":1219,"href":"https:\/\/epinutrition.org\/index.php?rest_route=\/wp\/v2\/pages\/198\/revisions\/1219"}],"wp:attachment":[{"href":"https:\/\/epinutrition.org\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=198"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}